環境職業生殖危害（四）—鉛暴露工人受孕所需時間及其下一代出生異常與神經行為障礙之研究
Other Title
Environmental and occupational reproductive hazards (4) -
Time-to-pregnancy study, and adverse birth outcomes and
neurobehavioral deficits among the offspring of lead exposed
workers
Time-to-pregnancy study, and adverse birth outcomes and
neurobehavioral deficits among the offspring of lead exposed
workers
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
陳保中
DOI
912320B002168
Abstract
Environmental and occupational lead exposure
induced health effect has been widely explored in
several decades. Lead might produce adverse effect to
nervous system and influence cognition, memory and
intelligence. However, few studies have yet
investigated its effect on reproduction and potential
effect on offspring. The present study was a
retrospective cohort study. We selected 34 valid
children whose ages were between six and eight years
and one or both of their parents worked at lead battery
factories before their deliveries. We individually
interviewed their parents to complete questionnaire
and conducted a neurobehavioral test using Chinese
version neurobehavioral performance system (NES2).
We used annual examination of blood lead and divided
into three groups, namely, paternal, maternal and
parental exposure whose mean blood lead were 23.3,
14.0 and 25.5µg/dl, respectively. The results showed
error counts of continuous performance test would
significantly increase with an elevation of prenatal lead
exposure dose. Moreover, we selected the children of
an elementary school in non-industrial area as a
reference population. We used a 1:4 ratio of exposure
to non-exposure subjects with same gender and age.
These 136 children subgroup were considered as a
non-exposure group. After controlling potential
confounders there were significantly differences
between exp osure and non-exposure group in several
test items such as finger tapping and continuous
performance test. The study was the first time to
measure neurobehavioral effect of prenatal lead
exposure in school age. The results demonstrated
prenatal lead exposure might induce minimal effect of lately neurobehavioral development. Our limited
evidence may come from small sample size, lack of lead
exposure data after delivery, and insensitive
neurobehavioral measure for the lead effects.
Subjects
children
lead
neurobehavioral test
prenatal exposure delayed effects
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
912320B002168.pdf
Size
65.58 KB
Format
Adobe PDF
Checksum
(MD5):9be0a69501e406a794e595738049a0fe