利用等距毛細管電泳法來研究富含三酸甘油酯之脂蛋白與臨床粥狀硬化性疾病發生之關連(3/3)
Other Title
Study on the Clinical Implication of Triglyceride-rich Lipoprotein of
Hypertriglyceridemic Patients by Capillary Isotachophoresis (3/3)
Hypertriglyceridemic Patients by Capillary Isotachophoresis (3/3)
Date Issued
2005
Date
2005
Author(s)
許秀卿
DOI
932314B002017
Abstract
Increasing experimental and clinical evidences suggest that tiglyceride-rich
lipoprotein (TGRL) play a significant role in the pathogenesis of atherosclerosis. The
TGRL is composed of a number of different lipoprotein and can be identified,
separated and/or quantified in plasma according to their density, charge, size, specific
lipid component, apoprotein composition. This study is nevertheless under way for
more accurate and clinical applicable TGRL assays that will be better define coronary
artery disease risk in patients with hypertriglyceridemia. Isotachophoresis , a high
resoluble technique of capillary electrophoresis, was used to separate plasma
lipoproteins according their net charge and without molecular sieve effects. In the
present study, plasma lipoproteins were separated into four subclasses of low density
lipoprotein (LDL1~ LDL4), five subclasses of TGRL (TGRL1~ TGRL5) and two
subclasses of high density lipoprotein (HDL1~ HDL2). The TGRL1 levels was higher
in hypertriglyceridemic patients with coronary artery diseases (CAD) as compared
with subjects without CAD (. 8.2±1.6 VS. 4.5±1.6). Interesting, the statistical analysis
showed that high levels of HDL2, TGRL1 and LDL4 subclasses were associated to
atherogenesis. Although other plasma lipoprotein subclass distributions were
individually different, they were not associated with other atherogenic risk factors or
related to atherogenesis. Some clinical cases showed the level of HDL2, TGRL1
and/or LDL4 subclasses distribution was predictive for CAD, however, the
characteristics and biological effects of these lipoprotein subclasses will be further exploed.
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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