正常血壓及高血壓大鼠延腦心臟副交感神經元活性及中樞連結之比較
Date Issued
2005
Date
2005
Author(s)
DOI
932311B002034
Abstract
In the present study, the neuronal activities and HR responses to glutamate solution (Glu,
10 mM) stimulation of the cardiac vagal preganglionic neurons (CVPNs) in nucleus
ambiguus (NA) of the 12-16 week old SHR were compared with aged matched normotensive
WKY (Wistar-Kyoto) rats and Wistar rats. Microinjection of different doses of 10 mM Glu
into the NA produced dose-dependent responses of heart rate (HR) in normotensive and
hypertensive rats. The maximal HR changes and threshold dose of Glu were not significantly
different in three strains, but there was a tendency that the threshold dose of SHR was largest,
then that of WKY rats and Wistar rats. The saturation dose of Glu to elicit the maximal HR
change was also significantly larger in SHR than that in Wistar rats. The maximal slope of
dose-response curve in Wistar rats is steepest in three strains. The results suggested that the
reactivity of CVPNs in NA to Glu stimulation might be lower in SHR than that in Wistar rats.
Most neurons in NA had respiratory firing patterns, few pulse-related neurons were observed
in three strains of rats.
Subjects
nucleus ambiguous
SHR
bradycardia
glutamate
cardiac vagal preganglionic neuron
Publisher
臺北市：國立臺灣大學生命科學系
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
932311B002034.pdf
Size
410.07 KB
Format
Adobe PDF
Checksum
(MD5):baed365ae3f777d6c5ed802b4391b973