胃液對用於藥物控制釋放高分子薄膜的影響
Date Issued
2001-07-31
Date
2001-07-31
Author(s)
謝銘鈞
DOI
892314B002325M08
Abstract
In this project, pH-sensitive membranes
for colon-specific drug delivery will be
synthesized by the covalent bonding of
glycine on poly(ethylene-co-vinyl alcohol)
(EVAL) membrane via isocyanation of
surface hydroxyl groups of EVAL membrane
and subsequent conversion to activated ester.
The membranes are functioning as protective
carriers of drugs in the stomach and small
intestine. Regardless of the EVAL membrane
and the glycine-immobilized EVAL
membrane, the 5-FU permeation at pH 2.0
was small, which indicates that drugs are
protected in the acidic environment. The
permeability of 5-FU with gastric juice was
the smallest. Gastric acid and gastrointestinal
motility present a major impediment to the
development of oral colon-specific delivery
medication.
Subjects
Gastric juice
polymer membrane
drug delivery
Publisher
臺北市：國立臺灣大學醫學工程學研究所
Type
report
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