Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan.
Journal
European journal of medical research
Journal Volume
29
Journal Issue
1
Start Page
286
ISSN
2047-783X
Date Issued
2024-05-14
Author(s)
Cheng, Wen-Chien
Sheu, Chau-Chyun
Wang, Ping-Huai
Hsieh, Meng-Heng
Chen, Ming-Tsung
Ou, Wei-Fan
Wei, Yu-Feng
Yang, Tsung-Ming
Lan, Chou-Chin
Wang, Cheng-Yi
Lin, Chih-Bin
Lin, Ming-Shian
Wang, Yao-Tung
Lin, Ching-Hsiung
Liu, Shih-Feng
Cheng, Meng-Hsuan
Peng, Chung-Kan
Chan, Ming-Cheng
Chen, Ching-Yi
Jao, Lun-Yu
Wang, Ya-Hui
Chen, Chi-Jui
Chen, Shih-Pin
Tsai, Yi-Hsuan
Cheng, Shih-Lung
Lin, Horng-Chyuan
Hsu, Wu-Huei
Abstract
Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB).
This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic). Furthermore, we established relationships between the severity of clinical factors, including symptom scores, pulmonary function, pseudomonas aeruginosa colonization, exacerbation and admission rates, and HRCT parameters using modified Reiff scores.
Data from 2,753 patients were classified based on HRCT patterns (cylindrical, varicose, and cystic) and severity, assessed by modified Reiff scores (mild, moderate, and severe). With increasing HRCT severity, a significant correlation was found with decreased forced expiratory volume in the first second (FEV1) (p < 0.001), heightened clinical symptoms (p < 0.001), elevated pathogen colonization (pseudomonas aeruginosa) (p < 0.001), and an increased annual hospitalization rate (p < 0.001). In the following multivariate analysis, elderly age, pseudomonas aeruginosa pneumonia, and hospitalizations per year emerged as the only independent predictors of mortality.
Based on our large cohort study, the simplified CT scoring system (Reiff score) can serve as a useful adjunct to clinical factors in predicting disease severity and prognosis among Taiwanese patients with NCFB.
SDGs
Type
journal article