Clinical significance of cytogenetics and interphase fluorescence in situ hybridization analysis in newly diagnosed multiple myeloma in Taiwan
Journal
Annals of Oncology
Journal Volume
16
Journal Issue
9
Pages
1530-1538
Date Issued
2005
Author(s)
Huang S.-Y.
Lee F.-Y.
Liu M.-C.
Wang C.-H.
Abstract
Background: The incidence of multiple myeloma (MM) is lower in Asia than in Western countries. However, it is not known whether cytogenetic abnormalities (CA) characteristic of MM in Asia differ from those documented in the West. Patients and methods: We analyzed CA by conventional cytogenetics (CG) and/or fluorescence in situ hybridization (FISH), assessed their clinical significance in 150 Chinese MM patients and compared our data with that derived from Western countries. Results: CA were detected by CG (CG_CA) in 44 (29.3%) of the 150 patients and by FISH (FISH_CA) in 59 (67%) of the 88 patients studied. Presence of either CG_CA or FISH_CA was associated with a poor prognosis. Patients with CG_CA and hyperdiploid chromosomes, always associated with several trisomies, had a longer survival (median 25 months versus 12 months; P=0.025) in comparison with those with non-hyperdiploid chromosomes, usually associated with a monosomy 13/partial deletion of 13q (Δ13) and a rearrangement of 14q32. A novel recurrent CG_CA, add (19)(p13), was found in four patients: all males with immunoglobulin G/λ isotypes, extramedullary myeloma at diagnosis and a poor prognosis. Three groups of patients with significantly different survival, CG_Δ13, FISH_Δ13 but without CG_Δ13, and neither CG_Δ13 nor FISH_Δ13 (median 9 versus 15 versus 32 months; P=0.013) were identified. Conclusions: We conclude that MM CA in our patients are similar to those noted in Western countries, and that combined CG and FISH analysis can predict prognosis. The clinical significance of add(19)(p13) needs to be further investigated. ? 2005 European Society for Medical Oncology.
SDGs
Other Subjects
dexamethasone; doxorubicin; melphalan; prednisolone; vincristine; adult; aged; article; autologous hematopoietic stem cell transplantation; cancer combination chemotherapy; chromosome aberration; chromosome analysis; clinical trial; comparative study; continuous infusion; cytogenetics; diploidy; disease association; dose response; female; fluorescence in situ hybridization; follow up; human; major clinical study; male; multiple myeloma; priority journal; prognosis; Taiwan; treatment outcome
Type
journal article