Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunity
Journal
Vaccine
Journal Volume
40
Journal Issue
47
Pages
6864
Date Issued
2022-11-08
Author(s)
Chang, Wei-Jung
Hsu, Chen-Yang
Ming-Fang Yen, Amy
Lin, Ting-Yu
Li-Sheng Chen, Sam
Hsiu-Hsi Chen, Tony
Abstract
In the face of rapid emerging variants of concern (VOCs) with potential of evading immunity from Beta to Omicron and uneven distribution of different vaccine brands, a mix-match strategy has been considered to enhance immunity. However, whether increasing immunogenicity using such a mix-match can lead to high clinical efficacy, particularly when facing Omicron pandemic, still remains elusive without using the traditional phase 3 trial. The aim of this study is to demonstrate how to evaluate correlates of protection (CoP) of the mix-match vaccination.
Subjects
COVID-19; Correlate of protection; Mix-match; Variant of concern
SDGs
Type
journal article