Paired Analysis of D-Dimer and Its Correlated Hemostatic Parameters in 30 Dogs with Neoplasms after Tumorectomy
Journal
Animals
Journal Volume
13
Journal Issue
6
Date Issued
2023-03-01
Author(s)
Abstract
Previous studies have reported that dogs with neoplasms had elevated D-dimer levels. However, few studies have addressed whether D-dimer could be an indicator of tumor burden. The clinical significance of paired analysis of pre- and post-operation of D-dimer levels in dogs has rarely been described. The present study investigated the values of D-dimer levels and their correlated hemostatic alterations in dogs with surgically removable benign and malignant tumors. This study analyzed 30 clinically healthy and 30 tumor-bearing dogs and evaluated the hemostatic functions including D-dimer, thromboelastography G (TEG G), fibrinogen, activated partial thromboplastin time (aPTT), prothrombin time, and platelet count. The median level of pre-treatment D-dimer was 0.8 µg/mL (range: 0.1–6.3 µg/mL), whereas the control dogs exhibited a median value of 0.1 µg/mL (range: 0.1–0.1 µg/mL, p < 0.0001). After tumorectomy, the median levels of D-dimer (p < 0.0001), fibrinogen (p < 0.0001), TEG G value (p < 0.01), and aPTT (p < 0.05) were significantly lower than those of the pre-treatment samples. However, further studies are needed to clarify the values of other hemostatic evaluations. The study revealed the clinical significance of D-dimer and its correlated hemostatic parameters by paired analysis in dogs with tumors. Though more cases are needed for solid confirmation, these values could be potential tumor biomarkers for dogs.
Subjects
D-dimer; hemostatic parameter; liquid biopsy; tumor biomarker
Other Subjects
activated partial thromboplastin time; animal experiment; animal tissue; anus tumor; area under the curve; Article; blood cell count; blood clotting; body weight; breast tumor; cancer surgery; canine transmissible venereal tumor; carcinoma; controlled study; diagnostic test accuracy study; dog; female; fibrinolysis; fibrosarcoma; hemostasis; histopathology; lipoma; liquid biopsy; lymph node; male; mastocytoma; melanoma; mouth squamous cell carcinoma; neoplasm; nonhuman; osteosarcoma; physical examination; platelet count; prothrombin time; receiver operating characteristic; retrospective study; sensitivity and specificity; soft tissue sarcoma; thromboelastography; thyroid carcinoma; tumor burden; tumor growth
Publisher
MDPI
Type
journal article