The Development of Polarization Sensitive Optical Coherence Tomography and its Application on Human Atherosclerosis
Date Issued
2005
Date
2005
Author(s)
Kuo, Wen-Chuan
DOI
zh-TW
Abstract
Optical coherence tomography (OCT) is a powerful tool capable of tomographic imaging based on low coherence interferometry. Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with additional image contrast of the sample. The added contrast is based on the ability of PS-OCT to detect the birefringent properties of a sample (phase retardation and fast-axis orientation) simultaneously.
In this research, a novel linear polarization-sensitive optical coherence tomography (Linear PS-OCT) system for extracting the birefringence property of samples is proposed. This is the extended setup from our previous proposed novel polarized common-path optical heterodyne interferometer for birefringence measurement of a quarter wave plate. To compare with conventional PS-OCT which uses circular polarized incident light, the linear PS-OCT shows three advantages: (1) Phase retardation (PR) of the sample can be obtained directly from the phase-difference between the polarization heterodyne signals when the fast axis (FA) of sample is nearly parallel or orthogonal to X-axis of the coordinates; (2) Common phase noise rejection mode leads to the immunity of background phase noise and laser frequency noise at the same time that results in a higher sensitivity on PR measurements; (3) the dynamic range of PR and FA are to in which PR is two times wider than that of conventional circular PS-OCT. Therefore, the tissue of a larger birefringence variation is preferential to be arranged.
In addition, we demonstrate the Circular PS-OCT for tomographic imaging of different kinds of atherosclerotic plaques. In this in vitro study, linear birefringence change in plaque due to the prominent deposition of collagen or calcium is demonstrated by correlating PS-OCT images with histology and the use of quantitative retardation curve analysis. Thus PS-OCT (i.e., the combination of high resolution structural imaging and linear birefringence imaging) is a potentially powerful tool for early diagnosis of atherosclerotic plaque development.
Subjects
極化
光學同調斷層攝影術
動脈粥狀硬化
polarization
optical coherence tomography
atherosclerosis
Type
thesis
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