Clinical manifestations and risk factors for mortality of patients with severe influenza during the 2016–2018 season
Journal
International Journal of Infectious Diseases
Journal Volume
95
Pages
347-351
Date Issued
2020
Author(s)
Abstract
Objectives: Influenza remains a crucial transmissible disease from community. We aim to identify risk factors associated with mortality among hospitalized patients with severe influenza. Methods: We retrospectively reviewed medical records of adult patients with laboratory-confirmed severe influenza at a medical center between January 2016 and December 2018. The primary outcome was 30-day all-cause mortality. Results: Totally 96 patients were enrolled, with 73 patients in the influenza A group and 23 in the influenza B group. Eighteen (18.8%) deaths occurred within 30 days of hospitalization, including 8 (11%) and 10 (43.5%) of each group. In multivariable Cox regression analysis, factors associated with mortality were underlying diseases of liver cirrhosis (adjusted hazard ratio [AHR], 3.94; 95% CI, 1.07–14.45) and rheumatologic diseases (AHR, 7.45; 95% CI, 2.34–23.69) and the diagnosis of influenza B (AHR, 4.33; 95% CI, 1.68–11.13). Conclusions: Clinician should early identify high-risk population and warning signs of severe influenza. Our results support the policy of quadrivalent influenza vaccination because influenza B could be associated with high mortality. ? 2020 The Author(s)
SDGs
Other Subjects
adult; aged; all cause mortality; Article; clinical feature; cohort analysis; controlled study; coronary artery disease; coughing; diarrhea; dyspnea; extracorporeal oxygenation; female; fever; headache; hospitalization; human; influenza A; influenza B; liver cirrhosis; major clinical study; malaise; male; malignant neoplasm; mental disease; outcome assessment; retrospective study; rheumatic disease; rhinorrhea; risk factor; survival rate; thorax pain; complication; influenza; middle aged; mortality; proportional hazards model; risk factor; season; influenza vaccine; Aged; Cohort Studies; Female; Hospitalization; Humans; Influenza Vaccines; Influenza, Human; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Seasons
Publisher
Elsevier B.V.
Type
journal article