Finite element analysis of slow drug release through deformed coating film: effects of morphology and average thickness of coating film
Resource
International Journal of Pharmaceutics 234 (1-2): 25-42
Journal
International Journal of Pharmaceutics
Journal Issue
234
Pages
25-42
Date Issued
2002
Date
2002
Author(s)
Chen, B.-H.
Lee, D.J.
DOI
246246/2006111501222701
Abstract
This paper, a continuation of our previous work, is a presentation of the effect of the morphology and the average
thickness of the deformed coating films on the slow diffusional release characteristics analyzed numerically under the
constraints of the constant volume of the drug matrices and the coating films, if the films have the same average
thickness. Increasing the average thickness of the coating films slows down the fractional release and the average
release rate of the drug and smoothen the initial burst of the drug, as well as increase the initial lag time. The effect
due to deformation of the coating films on these diffusional release characteristics are found to be less significant with
the increasing average thickness of the coating films. Interestingly initial lag times are found to be the same for the
coated particles having the same smallest thickness but different average thickness of coating films. The effect due to
the change in the average thickness of the coating films on the characteristics of the slow controlled-release is
discussed to shed light on the design of a better controlled-release device.
Subjects
Controlled-release
Deformation
Morphology
Film thickness
Coating film
Diffusional release
Publisher
Taipei:National Taiwan University Dept Mech Engn
Type
journal article
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