Guidelines and definitions for research on epithelial-mesenchymal transition
Journal
Nature reviews. Molecular cell biology
Journal Volume
21
Journal Issue
6
Pages
341
Date Issued
2020-06
Author(s)
Yang, Jing
Antin, Parker
Berx, Geert
Blanpain, Cédric
Brabletz, Thomas
Bronner, Marianne
Campbell, Kyra
Cano, Amparo
Casanova, Jordi
Christofori, Gerhard
Dedhar, Shoukat
Derynck, Rik
Ford, Heide L
Fuxe, Jonas
García de Herreros, Antonio
Goodall, Gregory J
Hadjantonakis, Anna-Katerina
Kalcheim, Chaya
Kalluri, Raghu
Kang, Yibin
Khew-Goodall, Yeesim
Levine, Herbert
Liu, Jinsong
Longmore, Gregory D
Mani, Sendurai A
Massagué, Joan
Mayor, Roberto
McClay, David
Mostov, Keith E
Newgreen, Donald F
Nieto, M Angela
Puisieux, Alain
Runyan, Raymond
Savagner, Pierre
Stanger, Ben
Stemmler, Marc P
Takahashi, Yoshiko
Takeichi, Masatoshi
Theveneau, Eric
Thiery, Jean Paul
Thompson, Erik W
Weinberg, Robert A
Williams, Elizabeth D
Xing, Jianhua
Zhou, Binhua P
Sheng, Guojun
Abstract
Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
Other Subjects
molecular marker; carcinogenesis; cell plasticity; conceptual framework; consensus; epithelial mesenchymal transition; fibrosis; history of medicine; malignant neoplasm; medical research; medical terminology; practice guideline; priority journal; Review; animal; cell motion; developmental biology; human; medical research; neoplasm; nomenclature; pathology; Animals; Biomedical Research; Cell Movement; Cell Plasticity; Consensus; Developmental Biology; Epithelial-Mesenchymal Transition; Humans; Neoplasms; Terminology as Topic
Publisher
NATURE PUBLISHING GROUP
Type
journal article