Adult Fanconi Syndrome with Proximal Muscle Weakness and Hypophosphatemic Osteomalacia: Report of a Case
Resource
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION v.93 n.8 pp.709-714
Journal
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
Journal Volume
v.93
Journal Issue
n.8
Pages
709-714
Date Issued
1994
Date
1994
Author(s)
LIAN, LI-MING
CHANG, YANG-CHYUAN
YANG, CHIH-CHING
YANG, CHIH-CHAO
KAO, KO-PEI
Abstract
A 42-year-old female presented with progressive proximal muscle weakness, generalized hyperreflexia, marked bone pain, severe lumbago and knee arthralgia. Electromyographic study showed short-duration (5-10 msec) , variable amplitude( 200-2500 μV) polyphasic potentials. A muscle biopsy specimen revealed non-specific type II fiber atrophy. After a compregensive laboratory work-up, adult Fanconi syndrome was diagnosed. The patient's symptoms, including bone pain and proximal muscle weakness, were relieved after a six-week supplement of tricalcium phosphate, vitamin D3 and sodium bicarbonate. The hyperreflexia also became less brisk.#0092 #