Conjunctivitis Does Not Increase With Longer Duration of Lebrikizumab Exposure in Patients With Moderate-to-Severe Atopic Dermatitis
Journal
SKIN: Journal of Cutaneous Medicine
Journal Volume
7
Journal Issue
6
Date Issued
2023-11-01
Author(s)
Armstrong, April
Wollenberg, Andreas
Bruin-Weller, Marjolein de
Lio, Peter A.
Natalie, Chitra R.
Zhao, Fangyi
Atwater, Amber Reck
Jimenez, Gemma
Vestergaard, Christian
Abstract
BACKGROUND AD is a chronic skin disease that can be a serious burden, affecting sleep, daily activities, and social relationships1 Lebrikizumab is a monoclonal antibody that binds with high affinity and slow off-rate to IL-13, thereby blocking the downstream effects of IL-13 with high potency2 Integrated safety data for lebrikizumab treatment in moderate-to-severe AD has been previously published in Phase 2 and 3 clinical trials3-6 Conjunctivitis and keratitis are events of special interest in moderate-to-severe AD and are reported more frequently in lebrikizumab-treated patients7 OBJECTIVE To further characterize patient-reported conjunctivitis and keratitis AEs in patients with moderate-to-severe AD participating in lebrikizumab clinical trials for ADCONCLUSIONS The majority of conjunctivitis and keratitis cluster events reported by lebrikizumab-treated patients were mild or moderate in severity, did not lead to treatment discontinuation, and were resolved or resolving at the time of the database lock The majority of conjunctivitis cluster events were reported during the first 16 weeks of treatment Incidence rate of conjunctivitis and keratitis cluster events did not increase with longer duration of exposure Patients with medical history of conjunctivitis may have higher risk of developing treatment-emergent conjunctivitis or keratitis
Type
journal article