The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population
Journal
Clinical Epigenetics
Journal Volume
15
Journal Issue
1
Pages
87
Date Issued
2023-05-17
Author(s)
Abstract
Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has been shown to decrease adiponectin levels in vitro and in vivo studies. However, the role of angiotensin I-converting enzyme (ACE) gene polymorphism and epigenetic changes in the relationship between DEHP exposure and adiponectin levels is not well understood.
Subjects
5mdC/dG; Adiponectin; DEHP (di-(2-ethylhexyl) phthalate); Epigenetic modifications; Glucose homeostasis; MEHP (mono(2-ethylhexyl) phthalate)
SDGs
Publisher
Springer Nature
Type
journal article