Family history of obesity related metabolic diseases as the risk factor of metabolic disturbances in schizophrenic patients receiving antipsychotics
Date Issued
2008
Date
2008
Author(s)
Chen, Po-Yu
Abstract
Objective:besity and diabetes mellitus are common side effects during antipsychotics treatment. These side effects may predispose cardiovascular diseases and decrease antipsychotics compliance in schizophrenic patients. Higher prevalence of metabolic diseases in schizophrenic patients was frequently reported in many countries. However, there are not many studies of the prevalence of metabolic diseases in community patients in Taiwan. Different effects on metabolic disease among various antipsychotics have been broadly discussed. However, clinical risk factors focusing on patient aspects still need to be further clarified. Family history was demonstrated as an important risk factor for metabolic diseases in general population. However, whether family history us also important for antipsychotics related metabolic disease is still an unresolved question. Our study aimed to provide reference for prevalence of metabolic disease in community schizophrenic patient in our country. Furthermore, this study examined the influence of family history on the metabolic outcomes related to antipsychotics treatmentsethods:olunteer schizophrenic patients were recruited during a disease screening activity, sponsored by Taipei Public Health Bureau. Schizophrenic who live in community and half-way houses were invited. Personal interview for clinical information were performed. All patients receive anthropometric measurements and fasting blood sampling to evaluate metabolic disease status. Prevalence of metabolic diseases among our patients was described. Multiple logistic regression model was use to define the metabolic family histories risk on various metabolic outcomes.esults:otally 307 patients were included in this study. Our analysis revealed prevalence in these patients were 60% for overweight, 30% for obese, 33.01% for metabolic syndrome, 33.66% for hypertension, 10.46% for diabetes mellitus and 9.48% in hypercholesterolemia. Most of these prevalence rates were higher than general population. Males tend to have hypertension. Females were found to have more diabetes and central obesity. Antipsychotics effects on metabolic diseases were not significant distinct in our study. Family history of DM elevated the risk to 2.35 in overweight, 2.01 in obesity, 2.07 in central obesity and 3.31 in DM. In addition, family history of DM increases 4.95 kg of mean body weight and 2.11 of body mass index. Family history of DM could be a predictor for overweight, obesity, central obesity and DM when patient receiving antipsychotics and as a reference for medical decision. Also, our study found interaction between antipsychotics and family history of DM , comparing to those without family history of DM, typical and second-generation antipsychotics generated more prominent risks for central obesity. Other metabolic disease family histories didn’t showed significant correlation with the metabolic outcomes in schizophrenic patients receiving antipsychotics. There are several limitations of this study. First of all, only current drug information was available. Second, there are many kinds of drugs in this study and the sample size for single drug is too small to clarify the specific drug effect. Also, information about family history was self-reported .It may be under estimated due to impaired cognitive function of schizophrenic patients. onclusion:he prevalence of metabolic diseases for schizophrenic patients in community was higher than the general population. Specific gender differences were found. Family history of DM predicts overweight, obesity, central obesity and DM in schizophrenic patient with antipsychotics treatments.
Subjects
schizophrenia
antipsychotics
obesity
diabetes mellitus
metabolic syndrome
risk factor
family history
SDGs
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