KMO as a novel diagnostic and prognostic biomarker in canine mammary gland tumors
Date Issued
2011
Date
2011
Author(s)
Chiang, Yi-Lun
Abstract
Tumor biomarkers are developed to indicate tumor status, clinical outcome or prognosis. Due to the involvement in tumor progression, most biomarkers are often used to monitor tumor development or exploit treatments for patients. Human epidermal growth factor receptor 2 (HER-2), estrogen receptor (ER) and progesterone receptor (PR) are known authentic biomarkers applied for routine examinations for human breast cancer; however, compared to their human counterparts, there are no effective biomarkers for diagnosing canine mammary gland tumor (cMGT). Our previous study has shown screening the gene expression of kynurenine 3-monooxygenase (kmo), an enzyme involved in tryptophan metabolism, could predict tumor malignancy and survival time of cMGT-suffering dogs. Here we intend to confirm if KMO could be a real cancer biomarker by investigating its protein expression in a serious of 54 cMGT cases, 29 of them were benign and 25 malignant collected at the Veterinary Hospital of National Taiwan University (NTU) with immunohistochemistry. The results indicated about 73.3% of malignant cMGT showed strong expression of KMO, and patients with strong KMO expression had markedly lower overall survival rate than those with negative or weak ones. Comparing to KMO investigations, increasing HER-2 manifestation was also shown to correlate with tumor size and cMGT stages. A positive correlation between KMO and Ki-67 expression was found in our cMGT cases and it suggests KMO may contribute to tumor development by promoting cell proliferation. This study demonstrated KMO as a potential biomarker in tumor diagnosis and might open new perspectives for clinical applications of cMGT.
Subjects
Canine mammary gland tumor (cMGT)
biomarkers
Kynurenine 3-monooxygenase (KMO)
HER-2
SDGs
Type
thesis
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