Detection of Polystyrene Beads Concentration Using an SOI-MEMS Differential Rotational Thermal Piezoresistive Resonator for Future Label-Free Biosensing Applications
Journal
IEEE Sensors Journal
Journal Volume
21
Journal Issue
19
Pages
21400-21409
Date Issued
2021
Author(s)
Abstract
This work shows a differential rotational thermal piezoresistive resonator (DR-TPR) design, fabrication, and characterization. The resonator uses silicon on insulator (SOI) microelectromechanical systems (SOI MEMS) technology. The sensing of carboxyl-polystyrene beads requires estimating the variation in the frequency of the resonator. It can serve as an alternative enabling technology to detect small molecules having wide implementations in clinical and industrial applications. The resonator uses a negative frequency shift to find the change in the mass due to the chemical absorption of the carboxyl-polystyrene beads on the DR-TPR surface. The method of using DR-TPR can attain label-free detection for many future biomarkers. The use of carboxyl-polystyrene beads to showcase the potential of DR-TPR as a mass sensor for future chemical/biosensing applications is the highlight of the paper. It includes the characterization in different concentrations of immobilization on the resonator surface. The work shows the operation of the resonator in an ionic buffer solution which is crucial for its future applications. The Q value of 80 with differential feedthrough cancellation is measured in phosphate-buffered saline (PBS) using DR-TPR. ? 2001-2012 IEEE.
Subjects
frequency shift
mass sensor
polystyrene beads
SOI MEMS
Thermal piezoresistive resonator (TPR)
viscous damping
MEMS
Microelectromechanical devices
Polystyrenes
Silicon on insulator technology
Biosensing applications
Frequency shift
Mass sensor
Piezo-resistive
Polystyrene beads
Silicon on insulator
Silicon on insulator MEMS
Thermal
Thermal piezoresistive resonator
Viscous damping
Resonators
Type
journal article