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Sex as a Moderating Factor in the Relationship Between Hippocampal Volume and Sensory Gating in Patients With Schizophrenia
Journal
Clinical EEG and Neuroscience
Journal Volume
50
Journal Issue
4
Pages
227-230
Date Issued
2019
Author(s)
Abstract
Building on the knowledge of sex differences in auditory sensory gating in schizophrenia and hippocampal involvement in sensory gating, this study aimed to investigate sex as a potential moderator of the association between hippocampal volume and P50 in schizophrenia. Auditory P50 gating and hippocampal volume were measured in 16 male and 15 female patients with schizophrenia. The correlations between hippocampal volume and P50 were analyzed in males and females separately, corrected for potential confounders, including age, duration of illness, and antipsychotic medication. Different associative patterns of hippocampal volume with P50 gating ratio and with P50 difference were found by sex. The results suggest sex may play a role in the physiology of sensory gating. ? EEG and Clinical Neuroscience Society (ECNS) 2019.
SDGs
Other Subjects
neuroleptic agent; adult; Article; auditory memory; auditory stimulation; clinical article; female; hearing test; hippocampus; human; language processing; male; mental disease; mismatch negativity; nuclear magnetic resonance imaging; P50 gating; Positive and Negative Syndrome Scale; priority journal; schizophrenia; sensory gating; sex difference; Tool Command batch processing language; auditory evoked potential; evoked response; hearing; hippocampus; pathology; pathophysiology; physiology; psychology; schizophrenia; sensory gating; sexual characteristics; Acoustic Stimulation; Adult; Auditory Perception; Evoked Potentials; Evoked Potentials, Auditory; Female; Hippocampus; Humans; Male; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Sex Characteristics
Type
journal article