Ultrasound Assisted Liposomal Cancer Therapy
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
DOI
922218E002043
Abstract
The prevalence of cancer disease is a major health problem worldwide. Cancer has been the
leading cause of death over the past two decades in Taiwan. This project focuses on the
development of a system involving targeting delivery for liposomal air-bubbles and
ultrasound-assisted release of the drug carried in liposome particles. The primary clinical interests
are stomach cancer and colon cancer diseases. In addition to drug delivery using liposome, the air
encapsulated in liposomes can also be used to enhance the contrast for ultrasound images, in
addition to the generation of cavitation induced by ultrasound wave. Tumor cells death will be
concomitant with the cavitation. Another aspect of the project aims at the development of two
micro-systems, one is the microdialysis perfusion system for the evaluation of liposomal targeting
efficiency, and the other is the microlight-guide system for evaluation of tumor functional images.
In addition, a non-invasive system using the oxygen quenched infrared phosphorescence will be
constructed to obtain the two dimensional tissue oxygen concentration profile. In the initial phase
of the project (i.e., first 9 months), the project has addressed the following issues:
- Effective induction and detection of acoustic cavitation
- Setup of an experimental system and simulator for analyzing cavitation
- Process and recipe for producing air encapsulated liposome microbubbles
- Development of the two micro-systems
- Study of the therapeutic effects of doxorubicin encapsulated liposome particles
- Cell culture for MKN45 with GFP
With the solid progress of the initial phase project, we will continue to coordinate and integrate
the results from sub-projects, and to evaluate the anti-tumoral efficacy of cavitation effects of the
air bubbles-loaded liposomal formulation and targeted drug delivery in cancer cells and cultured
cancer cells. The project will also move on to cancer therapy in the tumor xenograft model in
animals and in the in situ implanted cancers.
Subjects
ultrasound
contrast microbubbles
liposome
cavitation
cancer treatment
drug
delivery
delivery
SDGs
Publisher
臺北市：國立臺灣大學電機工程學系暨研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
922218E002043.pdf
Size
102.41 KB
Format
Adobe PDF
Checksum
(MD5):609188389870c30b85e851e9fa15640e