Boosting salt resistance of short antimicrobial peptides
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
57
Journal Issue
8
Pages
4050-4052
Date Issued
2013
Author(s)
Chu, Hung-Lun; Yu, Hui-Yuan; Chih, Ya-Han; Liang, Chong-Wen; Cheng, Hsi-Tsung; Cheng, Jya-Wei
Abstract
The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid �]-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich peptide S1 were diminished at high salt concentrations, whereas the activities of its �]-naphthylalanine end-tagged variants were less affected.
SDGs
Type
journal article