A study of Ion response under AC Electrical Bias
Date Issued
2007
Date
2007
Author(s)
Yin, You-Ben
DOI
zh-TW
Abstract
Typical micro-electrophoresis channel devices are usually applied with DC electric field, however, with continuous voltage supply, charge accumulation occurred only at one direction, which reduces data reproducibility during measurement. Besides, this effect change the environment during the measurement, it is difficult to exclude many complicate mechanisms which could affect measurement accuracy. So we decide to use AC signal measurement which can lead to regular charge recycling in micro-channel and avoid charge accumulation in the measurement environment. It ensures that the lowest noise exists in this environment and therefore increase the signal-to-noise (S/N) ratio. By measuring the phase delay phenomenon of bio-molecular under AC signal response, we can acquire data in a form of complex number. We can also calculate the individual response by dividing imaginary part with real part, both signals generated in the same mechanism. This measurement system implemented a lock-in amplifier with high frequency low noise pre-amplifier in advance and which can measure signals with high-sensitivity. We expect to develop a novel bio-molecular ID establishment from this new idea.
Subjects
微電泳通道元件
交流信號量測
相位響應
與環境無相關因子
鎖相放大器量測系統
Microelectrophoresis channel device
AC signal measurement
Phase response
Environment-independent factor
Lock-In amplifier measurement system
Type
thesis
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