Sjögren's Syndrome Antigen B Acts as an Endogenous Danger Molecule to Induce Interleukin-8 Gene Expression in Polymorphonuclear Neutrophils
Journal
PloS one
Journal Volume
10
Journal Issue
4
Pages
e0125501
Date Issued
2015-04-27
Author(s)
Abstract
Sjögren's syndrome antigen B is expressed in the nucleus and surface membrane of human polymorphonuclear neutrophils and is released after cell death. However, its biological role is not clear. This study is aimed to investigate the effect of Sjögren's syndrome antigen B on human polymorphonuclear neutrophils.
Subjects
SYSTEMIC-LUPUS-ERYTHEMATOSUS; TRANSFER-RNA SYNTHETASE; HEAT-SHOCK PROTEINS; DENDRITIC CELLS; CHEMOKINE RECEPTORS; IMMUNE-SYSTEM; DYING CELLS; LA PROTEIN; INFLAMMATION; ACTIVATION
SDGs
Publisher
PUBLIC LIBRARY SCIENCE
Type
journal article