Hyaluronan up-Regulates Il-10 Expression in Fibroblast-Like Synoviocytes from Patients with Tibia Plateau Fracture
Resource
JOURNAL OF ORTHOPAEDIC RESEARCH v.29 n.4 pp.495-500
Journal
Journal of Orthopaedic Research
Pages
495-500
Date Issued
2011
Date
2011
Author(s)
Abstract
Progression to osteoarthritis OA is a frequent sequela of severe articular fracture, particularly when weight- bearingjoints are involved. Prevention from post-traumatic OA remains a challenge. Hyaluronan HA therapy is reported to represent a safe and effective treatment for patients with OA and rheumatoid arthritis. However, the capacity of HA to prevent the occurrence of osteoarthritic changes in fractured joints has not been demonstrated. The present study was undertaken to examine the effects of HA on expression of six OA-related proteins in fibroblast-like synoviocytes FLS from 10 patients with tibia plateau fracture. OA-related factors were quantified using a sandwich enzyme-linked immunosorbent assay . Regardless of induction of the FLS with interleukin IL-1 beta, HA was found to down-regulate expression of catabolic factors IL-1 beta, matrix metalloproteinase-3, and tumor necrosis factor- alpha and to up-regulate production of anti catabolic factors tissue inhibitors of metalloproteinase-1 and metalloproteinase-2. HA also enhanced expression of IL-10, an antiinflammatory cytokine, in FLS. Our results indicated that HA can promote the expression of both antiinflammatory and structure- protective factors in FLS of patients with tibia plateau fracture.
Subjects
hyaluronan
tibia plateau fracture
synoviocyte
SDGs