行政院國家科學委員會專題研究計畫成果報告:免疫注射與隨後以弓蟲攻擊對細胞反應及細胞素表現之影響
Date Issued
1998
Date
1998
Author(s)
林大盛
DOI
872313B002086
Abstract
It is evident that cell-mediated immunity
(CMI) is more important than antibody in
protective immunity against Toxoplasma
gondii. The effect of CMI is mediated by
cytokines released mainly by T cells. Th1-
cytokines include IL-2 and IFN-g; and Th2-
cytokines include IL-4, IL-6, and IL-10.
They are antagonists. In general, Th1-
cytokines inhibit T. gondii proliferation and
Th2-cytokines promote severity of the
disease. IFN-g activates macrophages that
kill T. gondii. In addition, IL-6 assists
intracellular proliferation of T. gondii, and
IL-10 can inhibit the activity of IFN-g-
activated macrophages. However, recent
findings indicate that the relations between
Th1- and Th2-cytokines may be more
complicated. In the early stage of infection,
due to the inhibition of proinflammatory
cytokines by IL-4, the mortality of infected
mice is reduced. Similarly, IL-10 can restrain
toxoplasmic pathology in brain caused by
proinflammatory cytokines. Although both
types of cytokines may be released, one type
will be dominant. In the present study,
virulent strain RH will be used to study
antigenic and mitogenic responses of cells
from different sex, and the changes of
cytokine production in mice after
immunization and subsequent challenge with
T. gondii, in order to realize the roles played
by various cytokines.
Subjects
T cell
cytokine
cell-mediated immunity
Toxoplasma gondii
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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