Submerged cultivation of Antrodia cinnamomea for manufacturing the fermentation products possessing liver protective function
Date Issued
2008
Date
2008
Author(s)
Chen, Yi-Song
Abstract
The objective of this research was to establish proper fermentation conditions for submerged cultivation of Antrodia cinnamomea (AC) to produce a fermentation product with antihepatoma activity. AC was fermented for 1, 2, 4, 6 and 8 weeks with galactose, lactose and glucose as carbon sources of the submerged cultivation medium in 250 ml flask. The cell viability of Hep3B was more inhibited with the treatment of ethanolic extract of AC mycelia fermented for 8 weeks than those fermented for 1, 2, 4 and 6 weeks. The IC50 of ethanolic extract of AC mycelia fermented for 8 weeks with glucose as a carbon source (AC8-Em-glu) was 76.2
Subjects
A. cinnamomea
mycelia
hepatoma cell line
primary rat hepatocytes
CCl4
activity compounds
Type
thesis
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