In vitro assay identifying cisplatin resistance of head and neck squamous cell carcinoma
Journal
Oral Oncology Reports
Journal Volume
7
Date Issued
2023-09-01
Author(s)
Abstract
• Demonstrate patient tumor slice organoid (PTSO) as an in vitro rapid platform in identifying cisplatin-resistant patients. • Water soluble tetrazolium salt (WST-8) assay was used a viability test for determining cisplatin-resistance. • Cisplatin-resistance data obtained within 5 days after the initiation of PTSO culture. • Report cisplatin-resistance of a male 43 years with recurrent tongue cancer as validated from the patient's survival periods.
Subjects
Chemotherapy | Cisplatin resistance | Head and neck squamous cell carcinoma | Patient tumor slice organoid | Rapid drug susceptibility screening platform | Tetrazolium salt assay
SDGs
Type
other