Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease
Journal
Journal of Clinical Microbiology
Journal Volume
43
Journal Issue
9
Pages
4911-4913
Date Issued
2005
Author(s)
HSIAO, CHENG-HSIANG
WANG, CHENG-YI
Abstract
We present a case of fatal histoplasmosis in a patient with Addison's disease and long-term use of corticosteroid. The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass. He developed fulminant pneumonia and respiratory failure 9 years later. Nucleotide sequences of internal transcribed spacer regions of rRNA genes of the H. capsulatum isolate recovered from biopsied lung tissue and of the extracted fungal DNA from the laryngeal lesion were identical, indicating the recurrent nature of infection. Copyright ? 2005, American Society for Microbiology. All Rights Reserved.
SDGs
Other Subjects
amphotericin B; corticosteroid; ethambutol; fungal DNA; internal transcribed spacer; isoniazid; pyrazinamide; ribosome RNA; rifampicin; sultamicillin; tuberculostatic agent; Addison disease; aged; article; case report; clinical feature; diagnostic imaging; dyspnea; fever; fungus isolation; Histoplasma capsulatum; histoplasmosis; human; image analysis; larynx tumor; long term care; lung biopsy; lung tuberculosis; lymphadenopathy; male; nucleotide sequence; pneumonia; priority journal; recurrent infection; respiratory failure; sequence analysis; symptom; Taiwan; thorax radiography; transbronchial biopsy; Addison Disease; Aged; Aged, 80 and over; China; DNA, Ribosomal Spacer; Histoplasma; Histoplasmosis; Humans; Male; Molecular Sequence Data; Recurrence; RNA, Ribosomal, 5.8S; Sequence Analysis, DNA; Time Factors; Ajellomyces capsulatus
Type
journal article