Metformin use and cervical cancer risk in female patients with type 2 diabetes
Journal
Oncotarget
Journal Volume
7
Journal Issue
37
Pages
59548-59555
Date Issued
2016
Author(s)
Abstract
This study evaluated whether metformin may affect the risk of cervical cancer. The reimbursement databases of the Taiwan's National Health Insurance were used. Female patients with type 2 diabetes at an onset age of 25-74 years during 1999- 2005 and newly treated with metformin (n=132971, "ever users of metformin") or other antidiabetic drugs (n=6940, "never users of metformin") were followed for at least 6 months until December 31, 2011. The treatment effect of metformin (for ever versus never users, and for tertiles of cumulative duration of therapy) was estimated by Cox regression incorporated with the inverse probability of treatment weighting using propensity score. Analyses were also conducted in a 1:1 matched pair cohort based on 8 digits of propensity score. Results showed that the respective numbers of incident cervical cancer in ever users and never users were 438 (0.33%) and 38 (0.55%), with respective incidences of 68.29 and 121.38 per 100,000 person-years. The overall hazard ratio suggested a significantly lower risk in metformin users (0.558, 95% confidence intervals: 0.401-0.778). In tertile analyses, the hazard ratios (95% confidence intervals) for the first (<23.0 months), second (23.0-47.9 months) and third (>47.9 months) tertile of cumulative duration were 1.272 (0.904-1.790), 0.523 (0.366-0.747) and 0.109 (0.070-0.172), respectively. Findings were supported by the analyses in the matched cohort. In conclusion, metformin may significantly reduce the risk of cervical cancer, especially when the cumulative duration is more than 2 years.
Subjects
Cervical cancer; Diabetes mellitus; Metformin; Taiwan
SDGs
Other Subjects
insulin; metformin; pioglitazone; rosiglitazone; sulfonylurea; antidiabetic agent; metformin; adult; aged; Article; cancer incidence; cancer risk; cohort analysis; controlled study; female; human; major clinical study; national health insurance; non insulin dependent diabetes mellitus; probability; propensity score; proportional hazards model; risk reduction; Taiwan; uterine cervix cancer; chemically induced; incidence; middle aged; non insulin dependent diabetes mellitus; outcome assessment; procedures; statistics and numerical data; uterine cervix tumor; Aged; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; Metformin; Middle Aged; Outcome Assessment (Health Care); Propensity Score; Proportional Hazards Models; Taiwan; Uterine Cervical Neoplasms
Publisher
Impact Journals LLC
Type
journal article