Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients
Journal
Archives of Virology
Journal Volume
142
Journal Issue
7
Pages
1429-1440
Date Issued
1997
Author(s)
Abstract
Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.
SDGs
Other Subjects
Human T cell leukemia virus antibody; human T cell leukemia virus type II protein gp21; human T-cell leukemia virus type-II protein gp21; oncoprotein; virus envelope protein; adolescent; agglutination test; article; beta thalassemia; blood; child; classification; disease transmission; envelope gene; female; genetics; human; Human T cell leukemia virus 2; Human T cell leukemia virus infection; infant; male; molecular genetics; nucleotide repeat; nucleotide sequence; phylogeny; polymerase chain reaction; preschool child; prevalence; provirus; restriction fragment length polymorphism; Viet Nam; virology; Adolescent; Agglutination Tests; Base Sequence; beta-Thalassemia; Child; Child, Preschool; Female; Gene Products, env; Genes, env; HTLV-II Antibodies; HTLV-II Infections; Human T-lymphotropic virus 2; Humans; Infant; Male; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Proviruses; Repetitive Sequences, Nucleic Acid; Retroviridae Proteins, Oncogenic; Vietnam; HTLV; htlv ii; Human immunodeficiency virus; Human T-lymphotropic virus 2
Type
journal article