Genetic association analysis identifies a role for ANO5 in prostate cancer progression
Journal
Cancer Medicine
Journal Volume
9
Journal Issue
7
Pages
2372-2378
Date Issued
2020
Author(s)
Abstract
Anoctamins were originally identified as a family of calcium-activated chloride channels, but recently their roles in the development of different types of malignancies were suggested. Here, we evaluated the associations between 211 common single-nucleotide polymorphisms in 10 anoctamin genes with biochemical recurrence (BCR) after radical prostatectomy (RP) for localized prostate cancer. Four SNPs (ANO4 rs585335, ANO5 rs4622263, ANO7 rs62187431, and ANO10 rs118005571) remained significantly associated with BCR after multiple test correction (P?<.05 and q?=?0.232) and adjustment for known prognostic factors. Expression quantitative trait loci analysis found that ANO5 rs4622263 C and ANO10 rs118005571 C alleles were associated with decreased mRNA expression levels. Moreover, lower expression of ANO5 was correlated with more advanced tumors and poorer outcomes in two independent prostate cancer cohorts. Taken together, ANO5 rs4622263 was associated with BCR, and ANO5 gene expression was correlated with patient prognosis, suggesting a pivotal role for ANO5 in prostate cancer progression. ? 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Subjects
anoctamin; biomarker; prognosis; progression; prostate cancer
Other Subjects
adult; advanced cancer; aged; allele; ANO10 gene; ANO4 gene; ANO5 gene; ANO7 gene; Article; cancer growth; cancer localization; cancer prognosis; controlled study; correlational study; gene; gene expression; genetic association; genetic variability; human; major clinical study; male; outcome assessment; priority journal; prostate cancer; prostatectomy; single nucleotide polymorphism; disease exacerbation; follow up; genetic screening; genetics; middle aged; mortality; pathology; patient selection; prognosis; prostate tumor; quantitative trait locus; single nucleotide polymorphism; survival rate; ANO5 protein, human; anoctamin; tumor marker; Aged; Anoctamins; Biomarkers, Tumor; Disease Progression; Follow-Up Studies; Genetic Testing; Humans; Male; Middle Aged; Patient Selection; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms; Quantitative Trait Loci; Survival Rate
Publisher
Blackwell Publishing Ltd
Type
journal article