Arsenic metabolism, lactate dehydrogenase and electrocardiogram abnormality among residents in the arseniasis-endemic areas of southwestern Taiwan
Journal
Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment
Pages
155-156
ISBN
978-0415637633
Date Issued
2012
Author(s)
Abstract
Selenium (Se) is an essential trace element and absorbed selenium in the body is incorporated in selenocystine which is needed for synthesis of a number of important selenoproteins (Thomson 2004; Lobanov 2009). The arsenic-selenium antagonism has been demonstrated in various animal models and reported in literature (Gailer 2009; Gailer et al. 2000). Selenium is a potential chemopreventive agent for Arsenic (As) cancer. Selenium has been reported to form a complex selenobis(S-glutathionyl)arsinium ion in equimolar ratio with arsenic as a major metabolite in the liver and biliary tree and excreted (Gailer et al. 2000). Formation of this complex ion and hepatobiliary excretion is one of the basis of selenium countering arsenic toxicity.
SDGs
Publisher
Taylor and Francis - Balkema
Type
conference paper