A Fixed-Batch-Size Genomewide Scan Strategy in Linkage Analysis
Date Issued
2005
Date
2005
Author(s)
Chen, Shu-Jhen
DOI
zh-TW
Abstract
Using multiple markers to perform linkage analysis to localize genes for many monogenic human diseases has been shown successful during past years. The usual strategy is to take equally spaced markers to perform a global linkage search of the whole genome. The common approach is to type every individual in the sample at every marker locus. However, such an approach is extremely costly in labor and time because a lot of effort is wasted in genotyping large areas of the genome that do not show evidence for linkage. Developing an efficient search strategy for genome scans is therefore an important issue in linkage analysis.
In the present study, we proposed a fixed-batch-size genomewide scan strategy to select markers stepwisely to undergo linkage analysis. The transmission/disequilibrium test was used under the design of triad families. We conducted simulations to investigate the saving efficiency of the strategy. Our simulation results showed that: (1) this strategy could minimize the required number of markers in the study. (2) the required number of markers varies with the linkage disequilibrium coefficient and the mode of inheritance, but not with the disease position. The most efficient fixed-batch-size genomewide scan is for the multiplicative models, especially when the linkage disequilibrium coefficient is large.
Subjects
傳遞不平衡檢定
三元體
單一核苷
酸多型性
連鎖不平衡
transmission/disequilibrium test
triad
SNP
linkage disequilibrium
SDGs
Type
thesis
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