Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors
Journal
Clinical Infectious Diseases
Journal Volume
51
Journal Issue
8
Pages
976-979
Date Issued
2010
Author(s)
Yang C.-J.
Lee N.-Y.
Lin Y.-H.
Lee H.-C.
Ko W.-C.
Liao C.-H.
Wu C.-H.
Hsieh C.-Y.
Wu P.-Y.
Liu W.-C.
Chang Y.-C.
Abstract
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78). ? 2010 by the Infectious Diseases Society of America. All rights reserved.
SDGs
Other Subjects
penicillin G; reaginic antibody; adult; antibody blood level; article; clinical trial; confidence interval; female; Herxheimer reaction; human; Human immunodeficiency virus infection; major clinical study; male; multivariate analysis; priority journal; prospective study; risk factor; syphilis; Adolescent; Adult; Anti-Bacterial Agents; Exanthema; Female; Fever; HIV Infections; Humans; Incidence; Male; Middle Aged; Penicillins; Prospective Studies; Reagins; Risk Factors; Syphilis; Vasodilation; Young Adult
Type
journal article