High-Throughput Sequencing of Complementarity Determining Region 3 in the Heavy Chain of B-Cell Receptor in Renal Transplant Recipients: A Preliminary Report
Journal
Journal of clinical medicine
Journal Volume
11
Journal Issue
11
Date Issued
2022-05-25
Author(s)
Wu, Tsai-Hung
Liao, Hsien-Tzung
Li, Tzu-Hao
Tsai, Hung-Cheng
Lin, Niang-Cheng
Chen, Cheng-Yen
Tsai, Shih-Feng
Huang, Tzu-Hao
Tsai, Chang-Youh
Abstract
Graft failure resulting from rejection or any other adverse event usually originates from an aberrant and/or exaggerated immune response and is often catastrophic in renal transplantation. So, it is essential to monitor patients' immune status for detecting a rejection/graft failure early on.
Subjects
B cell; clonal diversity; complementary determining region 3 (CDR3); immune repertoire (iR); next-generation sequencing (NGS); renal transplantation
SDGs
Publisher
MDPI
Type
journal article