MOF-Based Single-Atom and Metal Cluster Catalysts by Room-Temperature Synthesis for Tumor Therapy
Journal
Advanced Healthcare Materials
ISSN
2192-2640
2192-2659
Date Issued
2025-05-27
Author(s)
Yu, Subin
Kang, Haeun
Jee, Seohyeon
Moon, WooYeon
Jang, Dohyub
Huang, Wen‐Tse
Kim, Dongjun
Chung, Kyungwha
Won, Dong‐Il
Park, Jungwon
Choi, Kyungmin
Kim, Sehoon
Lee, Luke P.
Kim, Dong Ha
Abstract
Metal–organic frameworks (MOFs) are widely used as substrates for creating single-atom catalysts due to their abundance of ligands, facilitating enzyme-like activity for biomedical applications. However, the high-temperature calcination process for single-atom catalysts limits economical, efficient, and large-scale synthesis. Here, a simple room-temperature synthesis of MOF-based single-atom and metal cluster catalysts is presented for tumor therapy. Fe/MOF is obtained through a coordination reaction at room temperature, while Au/MOF is synthesized from Au3+/MOF by introducing a reducing agent. Au/MOF effectively generates hydrogen peroxide (H2O2) from glucose, outperforming Au3+/MOF, and Fe/MOF subsequently produced hydroxyl radicals (•OH) by decomposing the generated H2O2via accelerated peroxidase-like activity in an acidic environment. In vitro and in vivo studies confirm a significantly enhanced cancer eradication ability compared to the PBS-treated group by combining cascade enzymatic activity, destruction of oxidative homeostasis, and excessive mitochondrial-mediated lipid peroxidation. The novel synthesis process of MOF-based metal single-atom catalysts establishes a new paradigm for fabricating effective enzyme-like nanomaterials for multimodal tumor therapy.
Subjects
glucose oxidase mimic
metal–organic framework
peroxidase mimic
single atom catalyst
tumor therapy
SDGs
Publisher
Wiley
Type
journal article