Construction of Biochemical Pathway Database System Base On Analysis Of Homologous proteins
Date Issued
2004
Date
2004
Author(s)
Chang, Shih-Hsian
DOI
zh-TW
Abstract
This thesis focuses on construction of predicted pathways database system. It is
getting important to know the co-working of genes and gene’s product. However,
using conventional methods to construct the pathway which describes
relationship of genes is too slow to satisfy the urgent demand. To find an
efficient method to construct pathway automatically will be helpful for
biochemist. There are some databases which predict metabolic pathways but not
signal transduction pathways. In the thesis we use the ontology of genes which is
already in Homologene database, the homologous relationship predicted by
BLAST based on the sequence similarities, and use the function of gene products
generated by KNN classifier, in order to construct the correspondence of genes
for new pathway generation. On the other hand, it is important to visualize the
predicted pathways. We use compound graph which can describe pathway well
as our system data architecture. The proposed predicting system provides the
biochemists a good solution to discover new pathways effectively and efficiently.
Subjects
生化途徑
資料庫系統
基因
蛋白質序列相似度
生化反應調控途徑
生化反應途徑
預測
prediction
gene
biochemical pathway
database system
pathway
protein sequence similarity
Type
thesis
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