Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra
Journal
Helvetica Chimica Acta
Journal Volume
87
Journal Issue
1
Pages
57-66
Date Issued
2004
Author(s)
Abstract
Abstract Four cyclic peptides, diandrine A–D ( 1 – 4 ), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(‐Gly 1 ‐Pro 2 ‐Trp 3 ‐Pro 4 ‐Tyr 5 ‐Phe 6 ‐), cyclo(‐Gly 1 ‐Pro 2 ‐Leu 3 ‐Pro 4 ‐Leu 5 ‐Trp 6 ‐Ser 7 ‐Ser 8 ‐), cyclo(Gly 1 ‐Gly 2 ‐Pro 3 ‐Tyr 4 ‐Trp 5 ‐Pro 6 ‐), and cyclo(Gly 1 ‐Gly 2 ‐Pro 3 ‐Tyr 4 ‐Trp 5 ‐Pro 6 ‐), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen‐induced platelet aggregation with an IC 50 value of 44.2 μ M .
Type
journal article