New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli
Resource
Steroids 74 (6): 543-547
Journal
Steroids
Journal Volume
74
Journal Issue
6
Pages
543-547
Date Issued
2009
Author(s)
Cheng, Shi-Yie
Huang, Ya-Chiang
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wang, Shang-Kwei
Duh, Chang-Yih
Abstract
Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4α-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages. © 2009 Elsevier Inc. All rights reserved.
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Type
journal article
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