Electroporation Enhanced Transdermal Drug Delivery for Melanoma Skin Cancer Therapy by Using DACH-Platinum Conjugated Hyaluronic Acid/Multi-walled Carbon Nanotube Mixtures.
Date Issued
2015
Date
2015
Author(s)
Hsu, Zong-Ping
Abstract
Skin cancer is a cancer lesion that Oriental less, but in foreign countries is complicated by high rates of cancer, into basal cell tumor, squamous cell tumors, melanoma. Our experiment is based on the melanoma cells as experimental, mainly because the disease is low, although he was only five percent of skin cancer in the left and right, but because of its high metastatic cause high mortality rate, so we choose in this group were the most experimental groups. Melanoma cells has many first-line drugs, such as Doxorubicin .Oxaliplatin and Cisplatin, etc., among which the most commonly used platinum-based drugs, so we use the active form DACHPt Oxaliplatin as chemotherapy drugs, in order to increase the penetration effect of percutaneous transmission and to enhance the effect for targeting tumor cells, we use hyaluronic acid (Hyaluronic acid, HA) not only as a drug carrier can enhance the penetration effect, its high biocompatibility also allows patients will not have adverse effects concerns. Human skin is divided into three layers, namely the epidermis. Dermis subcutaneous tissue, wherein the outermost layer of the epidermis cuticle compact arrangement protects the body, causing many drugs can not penetrate, so just increase the use of hyaluronic acid itself moist transparent ability degree is not enough, so we use electroporation (Electroporation) a way to increase the penetration, however electroporation Ford needs a higher number of cells in order to make the holes, we choose with multi-walled carbon nanotubes (MWNT) to this part of the problem, because the high aspect ratio of carbon nanotubes can amplify it has the effect of an electric field, so that we do not use a high number of Ford still achieve the effect of the cells to open pores. This paper is the use of hyaluronic acid after graft carbon nanotubes with platinum drugs to enhance the effect of electroporation treatment for skin cancer, and we have found our material for CD44 by the cells had better get toxic effect, and indeed carbon tubes with electroporation have better drug delivery effect, it is desirable to coordinate the way electroporation grafted hyaluronic acid drugs can contribute in different areas, whether in health or beauty treatment and so on.
Subjects
melanoma
hyaluronic acid
DACHPt
transdermal
Electroporation
SDGs
Type
thesis
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