A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children
Journal
Journal of Pediatrics
Journal Volume
158
Journal Issue
5
Pages
740-744
Date Issued
2011
Author(s)
Abstract
Objective: To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children. Study design: A total of 520 obese children aged 6-18 years were recruited. Their PNPLA3 rs738409 genotypes - CC, CG, or GG - were detected by the 5'-nuclease assay. The effects of the PNPLA3 rs738409 G allele on pediatric NAFLD were evaluated based on liver ultrasonography findings and mean serum alanine aminotransferase levels in these children. Results: NAFLD was present in 19.6% of the obese children. In comparison to the subjects with CC alleles, the risk of NAFLD was increased by 2.96-fold (95% CI, 1.57 to 5.59, P = .0008) in the subjects with CG alleles and by 5.84-fold (95% CI, 2.59 to 13.16; P < .0001) in those with GG alleles. Variant PNPLA3 rs738409 genotypes were associated with increases in mean serum alanine aminotransferase level of 4.77 IU/L (P = .0435) in subjects with CG alleles and of 10.86 IU/L (P < .0001) in those with GG alleles compared with subjects with CC alleles. Conclusions: The variant PNPLA3 rs738409 genotypes increased the risk of NAFLD in our population of obese Taiwanese children. The effect of the G allele on pediatric NAFLD followed a dominant genetic model. ? 2011 Mosby Inc. All rights reserved.
SDGs
Other Subjects
adiponectin; alanine aminotransferase; aspartate aminotransferase; membrane protein; protein pnpla 3; unclassified drug; adolescent; adult; alanine aminotransferase blood level; article; aspartate aminotransferase blood level; body mass; child; echography; female; gene frequency; genetic risk; genetic susceptibility; genetic variability; genotype; human; insulin resistance; major clinical study; male; nonalcoholic fatty liver; obesity; preschool child; priority journal; risk factor; single nucleotide polymorphism; Taiwan; waist circumference; Adolescent; Alleles; Child; DNA; Fatty Liver; Female; Genetic Predisposition to Disease; Genotype; Humans; Lipase; Liver; Male; Membrane Proteins; Obesity; Polymorphism, Single Nucleotide; Prevalence; Retrospective Studies; Risk Factors; Taiwan
Type
journal article