Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans
Journal
Journal of Environmental Biology
Journal Volume
28
Journal Issue
2 SUPPL.
Pages
349-357
Date Issued
2007
Author(s)
Abstract
Humans can be exposed to arsenic from a variety of environmental, occupational and medicinal sources. Exposure from drinking water is the most common source nowadays. Inorganic arsenic is metabolized by two main biochemical reactions: reduction and oxidative methylation. Recent studies have confirmed a reactivation of the toxic effects of arsenic associated with such methylation process, because the methylated metabolites, especially the trivalent forms, are more toxic than the inorganic arsenicals. Chronic exposure to arsenic can cause a variety of cancerous and non-cancerous health hazards in humans. The main non-cancerous health hazards include cardiovascular disease, skin lesions, neurological problems, diabetes mellitus and hypertension. ? Triveni Enterprises.
Subjects
Blackfoot disease; Health hazards; Human exposure; Inorganic arsenic; Neuropathy
SDGs
Other Subjects
arsenic; drinking water; arsenate; arsenic; drinking water; health impact; health risk; metabolism; methylation; pollution effect; pollution exposure; toxic substance; tumor; water quality; atherosclerosis; blackfoot disease; cardiovascular disease; chemical analysis; health hazard; human; long term exposure; methylation; neuropathy; review; skin defect; water contamination
Type
review