IMPACT OF COMPLEX POLYMORPHIC SYSTEM OF ABCB1 GENE ON THE EPILEPSY TREATMENT OUTCOME.
Resource
PHARMACOGENOMICS v.6 pp.411-417
Journal
PHARMACOGENOMICS
Journal Volume
v.6
Pages
411-417
Date Issued
2005
Date
2005
Author(s)
HUNG, CHIN-CHUAN
TAI, JOHN, JEN
LIN, CHUN-JUNG
Abstract
Objectives The aim of this study was to investigate the association of the complex haplotype system of ABCB1 gene with the epilepsy treatment response. Methods and results Ten polymorphisms were genotyped in 108 drug-resistant epileptic patients, 223 seizure-free patients and 287 normal controls. Highly significant linkage disequilibrium was shown among exon 12 C1236T, exon 21 G2677 T and exon 26 C 3435T. Haplotypic analysis demonstrated that patients with the C-G-C, T-G-C, and T-T-T haplotypes were more likely to be drug-resistant. Further analysis of haplotype combinations demonstrated that drug-resistant patients tended to have the CGC/CGC, CGC/TGC, CGC/TTT and TGC/TTT haplotype combinations over the seizure-free patients and controls (all p-values<0.0001). In contrast, patients with the TTC/TTC, TTC/CGT, TTC/TGT, CGT/CGT and TGT/CGT haplotype combinations were more likely to be seizure- free (all p- values<0.0001 except CGT/CGT (p=0.0063))./CGT haplotype combinations were more likely to be seizure- free (all p- values<0.0001 except CGT/CGT (p=0.0063)).
Subjects
MDR1
polymorphisms
epilepsy
linkage disequilibrium
Type
journal article