Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer
Journal
Journal of experimental & clinical cancer research : CR
Journal Volume
42
Journal Issue
1
Date Issued
2023-10-26
Author(s)
Hsu, Xiu-Rui
Wu, Jia-En
Wu, Yi-Ying
Hsiao, Sheng-Yen
Liang, Jui-Lin
Wu, Ya-Ju
Tung, Chia-Hao
Huang, Meng-Fan
Lin, Ming-Shiu
Chen, Yuh-Ling
Hong, Tse-Ming
Abstract
Lung cancer is the most common and deadliest cancer worldwide, and approximately 90% of all lung cancer deaths are caused by tumor metastasis. Tumor-derived exosomes could potentially promote tumor metastasis through the delivery of metastasis-related molecules. However, the function and underlying mechanism of exosomal long noncoding RNA (lncRNA) in lung cancer metastasis remain largely unclear.
Subjects
EGFR; Exosome; IGF1R; Lnc-MLETA1; Lung cancer metastasis; miR-186-5p; miR-497-5p
Type
journal article