Biocompatible, Surface Functionalized Mesoporous Titania Nanoparticles for Intracellular Imaging and Anticancer Drug Delivery.
Resource
Chemical Communications, 47(18), 5232-5234
Journal
Chemical Communications
Pages
5232
Date Issued
2011
Date
2011
Author(s)
Wu, Kevin C.-W.
Yamauchi, Yusuke
Hong, Chen-Yu
Yang, Ya-Huei
Liang, Yung-He
Funatsu, Takashi
Abstract
Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC50 ? 400 μg mL?1) and a large surface area (ca. 237.3 m2 g?1) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20. ? The Royal Society of Chemistry 2011.
SDGs
Other Subjects
doxorubicin; flavine mononucleotide; mesoporous titania nanoparticle; nanoparticle; phosphate; pralidoxime mesilate; titanium derivative; titanium dioxide; unclassified drug; article; biocompatibility; breast cancer; cancer cell; cell proliferation; controlled study; cytotoxicity; drug delivery system; female; human; human cell; porosity; surface property; transmission electron microscopy
Type
journal article
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