MiR-503 pleiotropically regulates epithelial-mesenchymal transition and targets PTK7 to control lung cancer metastasis
Journal
Cancer medicine
Date Issued
2023-05-22
Author(s)
Gow, Chien-Hung
Liu, Yi-Nan
Tsai, Meng-Feng
Chang, Tzu-Hua
Abstract
In lung cancer patients, most deaths are caused by the distant dissemination of cancer cells. Epithelial-mesenchymal transition (EMT) and collective cell migration are distinct and important mechanisms involved in cancer invasion and metastasis. Additionally, microRNA dysregulation contributes significantly to cancer progression. In this study, we aimed to explore the function of miR-503 in cancer metastasis.
Subjects
actin cytoskeleton; epithelial-mesenchymal transition; focal adhesion kinase; miR-503; protein tyrosine kinase 7
SDGs
Type
journal article