A mathematical model of cellular metabolism during ischemic stroke and hypothermia
Journal
IEEE Transactions on Biomedical Engineering
Journal Volume
61
Journal Issue
2
Pages
484-490
Date Issued
2014
Author(s)
Abstract
Stroke is a major cause of death and disability worldwide. Therapeutic hypothermia is a potentially useful neuroprotective treatment. A mathematical model of brain metabolism during stroke is extended here to simulate the effect of hypothermia on cell survival. Temperature decreases were set to reduce chemical reaction rates and slow diffusion through ion channels according to the Q10 rule. Heat delivery to tissues was set to depend on metabolic heat generation rate and perfusion. Two cooling methods, scalp and vascular, were simulated to approximate temperature variation in the brain during treatment. Cell death was assumed to occur at continued cell membrane depolarization. Simulations showed that hypothermia to 34.5 °C induced within 1-1.5 h of stroke onset could extend cell survival time by at least 5 h in tissue with perfusion reduced by 80% of normal. There was good agreement between simulated metabolite dynamics and those reported in rat model studies. ? 2013 IEEE.
Subjects
Cellular metabolism
hypoxia
ischemia
Membrane depolarization
stroke
Temperature decrease
Temperature variation
Therapeutic hypothermias
Cell death
Cell membranes
Mathematical models
Metabolism
Tissue
Hypothermia
ion channel
animal cell
animal experiment
animal model
article
astrocyte
body temperature disorder
brain ischemia
brain metabolism
brain tissue
capillary
cell death
cell membrane depolarization
cell metabolism
cell survival
chemical reaction
cooling
core temperature
extracellular space
heating
hypothermia
induced hypothermia
mathematical model
nerve cell
nonhuman
rat
tissue perfusion
Animals
Brain
Cell Hypoxia
Computer Simulation
Hypothermia, Induced
Models, Biological
Rats
Stroke
SDGs
Type
journal article