海洋微細藻類之抗癌、抗病毒藥物開發與其他活性物質探討
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
DOI
912323B002009
Abstract
This project aimed on the exploitation of bioactive compounds from microalgae to match the
need of NHRI in drug development. For the purpose, algae indigenous to Taiwan were isolated,
cultivated, and harvested for the previous screening of cytotoxicities. It was found dinoflagellate
belonging to the genus of Amphidinium and Prorocentrum exerted strong cytotoxicities with high
frequency. The potentially active strains of these genuses were cultivated to larger volume for
purifying enough bioactive compounds inside. By the way, twenty-six compounds were purified
from four Amphidinium and Prorocentrum strains respectively, and the structures of 19
compounds were fully elucidated. Five of them were new compounds and 1 with new skeleton;
other 7 compounds whose structures were partially elucidated were identified as new compounds
or new skeletal compounds. At least 6 of them exerted strong cytotoxicities, indicating the
potency to explore anti-cancer drugs from the microalgae of Taiwan.
Macrolides produced by marine creatures were known to exerted strong cytotoxicity. The
complex structures and the low contents, however, restricted their utilizations on cancer therapy,
with no exceptions for prorocentrolides found in our research. It was overcome, however, by
finding a strain of Prorocentrum with high prorocentrolide content, indicating the value to keep a
library of algal strains.
Subjects
microalgae, anti-cancer, bioactive compound, macrolide
SDGs
Publisher
臺北市：國立臺灣大學漁業科學研究所
Type
journal article
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