Identification and Study of Genes that Regulate T Lymphocyte Differentiation and Immune Response (1/3)
Date Issued
2005
Date
2005
Author(s)
繆希椿
DOI
932320B002078
Abstract
Naïve CD4 + T lymphocytes differentiate into two distinct subsets, T helper 1
(Th1) and T helper 2 (Th2), upon T cell receptor engagement. Mature effectors Th
lymphocyte plays an orchestrated role in the immune system. Th1 cells produce IFN摯瑬敳獩 ,
IL2 and lymphotoxin, and mediate responses of delayed-type hypersensitivity and
activation of macrophage. Th1 responses are important for protection against
intracellular pathogens and mediate organ-specific autoreactive immune responses.
Conversely, Th2 cells produce IL4, IL5, IL6, IL9, IL10 and IL13, and mediate
antibody production by B cells. Th2 responses are critical in protection against
helminths and responsible for anti-inflammatory reactions.
Recent studies have shown that T lymphocyte specific transcription factors T-bet,
GATA3 and c-MAF have essential roles in the Th1/Th2 development. T-bet is the
master regulator for the development of the Th1 cell lineage, while GATA3 and
c-MAF are crucial for the development of the Th2 cell lineage. Other factors, such as
cytokines, polypeptide mediator Eta1, chemokine MCP-1, signal transducer and
activator of transcription 4 (STAT4), and STAT6 also influence the T lymphocyte
differentiation. However, many studies indicate that some other factors involved in Th
differentiation are yet to be identified. Therefore, we intend to effectively screen and
identify the factors crucial for T lymphocyte differentiation (Specific Aim 1) and
study their roles in Th1/Th2 and immune response in vitro and in vivo (Specific Aim
2&3).
The goal of this proposal is to provide a better insight of the molecular and
cellular mechanisms by which genes regulate T Lymphocyte differentiation and
immune response. Furthermore, we hope to establish the Th1/Th2-skewed mouse
models for better understanding and controlling of Th1-mediated diseases, such as
organ-specific autoimmunity diseases and Th2-mediated diseases, such as asthma and
allergy.
Subjects
T Lymphocyte
Gene Regulation
Immune Response
Publisher
臺北市：國立臺灣大學醫學院免疫學研究所
Type
journal article
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