The Correlation of LIGHT and The Outcome of Epithelial Ovarian Carcinoma Patients
Date Issued
2015
Date
2015
Author(s)
Huang, Yi-Yao
Abstract
Objective To explore the correlation between HVEM、LIGHT and BTLA expression levels in cancerous tissue and the prognosis of patients with epithelium ovarian carcinomas. Materials and Methods The expression levels of HVEM、LIGHT、BTLA in epithelial ovarian carcinoma tissue were measured by reverse-transcription polymerase chain reaction, (RT-PCR) and real-time quantitative reverse-transcription polymerase chain reaction (RTQ RT-PCR). Clinico-pathologic parameters and biomarkers including disease stage, histology, tumor grade, surgical status, chemotherapeutic response and HVEM, LIGHT and BTLA expression levels in cancerous tissues were used for prognostic factors to predict the disease-free survival (DFS) and overall survival (OS) of ovarian cancer patients. Results The mean age of 254 ovarian cancer patients are 53.3 years old. Sixty-one out of 254 were diagnosed as early ovarian carcinomas while the remaining 193 were as advanced diseases. 57.8% of the studied population were serous ovarian carcinoma. LIGHT could be detected in all the cancerous specimens but BTLA only could be detected in 154 cases. In the multivariate analysis, sub-optimal surgery (residual tumor size > 1 cm) [hazard ratio (HR): 2.9, 95% confidence interval (CI) 1.7-2.8, p<0.001] and higher LIGHT expression levels [HR: 1.6, 95% CI 1.2-2.1, p=0.001] were independent prognostic factors of OS. In addition, sub-optimal surgery (residual tumor size > 1 cm) [HR: 2.1, 95% CI 1.5-2.9, p<0.001] and higher LIGHT expression levels [HR: 2.1, 95% CI 1.7-2.5, p<0.001] were independent prognostic factors of DFS. According the expression levels of LIGHT in cancerous tissues, the studied could be divided into three groups. In this study, the patients with lower LIGHT expression levels had longer DFS (Ptrend<0.001) and OS (Ptrend=0.03) than those with higher LIGHT expression levels. Furthermore, the LIGHT expression levels positively correlated to the BTLA expression levels (p<0.001) in this study. The tumors in the LIGHT higher expression group were less chemo-seneitive (p<0.001). Conclusions The patients with higher LIGHT expression levels in ovarian cancerous tissue would have shorter DFI and OS. The LIGHT expression levels may be a potential biomarker for predicting the prognosis of ovarian cancer patients.
Subjects
ovarian cancer prognosis
caner-immunology
SDGs
Type
thesis
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